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Publié le 15-11-2011

La fondation RITC est fière d’annoncer les publications issues des programmes qu’elle soutient

AAP au fil de l’eau 2011

Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules.
Moussion C, Girard JP. Nature. 2011 Nov 13. doi : 10.1038/nature10540. [Epub ahead of print] PMID : 2080953

AAP au fil de l’eau 2010

Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3’-end processing and function during DNA damage.
Decorsière A, Cayrel A, Vagner S, Millevoi S. Genes Dev. 2011 Feb 1 ;25(3):220-5.

Projet 3R - Cancer

DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
Lemée F, Bergoglio V, Fernandez-Vidal A, Machado-Silva A, Pillaire MJ, Bieth A, Gentil C, Baker L, Martin AL, Leduc C, Lam E, Magdeleine E, Filleron T, Oumouhou N, Kaina B, Seki M, Grimal F, Lacroix-Triki M, Thompson A, Roché H, Bourdon JC, Wood RD, Hoffmann JS, Cazaux C. Proc Natl Acad Sci U S A. 2010 Jul 27 ;107(30):13390-5.

Projet Hémopathies malignes

Wide diversity of PAX5 alterations in B-ALL : a Groupe Francophone de Cytogenetique Hematologique study.
Coyaud E, Struski S, Prade N, Familiades J, Eichner R, Quelen C, Bousquet M, Mugneret F, Talmant P, Pages MP, Lefebvre C, Penther D, Lippert E, Nadal N, Taviaux S, Poppe B, Luquet I, Baranger L, Eclache V, Radford I, Barin C, Mozziconacci MJ, Lafage-Pochitaloff M, Antoine-Poirel H, Charrin C, Perot C, Terre C, Brousset P, Dastugue N, Broccardo C. Blood. 2010 Apr 15 ;115(15):3089-97.

Projet Cancers digestifs

Control of contact-inhibition by 4E-BP1 upregulation.
Azar R, Susini C, Bousquet C, Pyronnet S. Cell Cycle. 2010 Apr 23 ;9(7).

MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions.
du Rieu MC, Torrisani J, Selves J, Al Saati T, Souque A, Dufresne M, Tsongalis GJ, Suriawinata AA, Carrère N, Buscail L, Cordelier P. Clin Chem. 2010 Apr ;56(4):603-12.

4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation.
Azar R, Alard A, Susini C, Bousquet C, Pyronnet S. EMBO J. 2009 Nov 18 ;28(22):3514-22.

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.
Guillermet-Guibert J, Davenne L, Pchejetski D, Saint-Laurent N, Brizuela L, Guilbeau-Frugier C, Delisle MB, Cuvillier O, Susini C, Bousquet C. Mol Cancer Ther. 2009 Apr ;8(4):809-20.

Clinical fate of branch duct and mixed forms of intraductal papillary mucinous neoplasia of the pancreas.
Bournet B, Kirzin S, Carrère N, Portier G, Otal P, Selves J, Musso C, Suc B, Moreau J, Fourtanier G, Pradère B, Lazorthes F, Escourrou J, Buscail L. J Gastroenterol Hepatol. 2009 Jul ;24(7):1211-7.

Projet Microenvironnement tumoral

Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells.
Dumartin L, Quemener C, Laklai H, Herbert J, Bicknell R, Bousquet C, Pyronnet S, Castronovo V, Schilling MK, Bikfalvi A, Hagedorn M. Gastroenterology. 2010 Apr ;138(4):1595-606, 1606.e1-8

Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.
Laklai H, Laval S, Dumartin L, Rochaix P, Hagedorn M, Bikfalvi A, Le Guellec S, Delisle MB, Schally AV, Susini C, Pyronnet S, Bousquet C. Proc Natl Acad Sci U S A. 2009 Oct 20 ;106(42):17769-74.

Projet RIBO-CANCER

Widespread Estrogen-Dependent Repression of microRNAs Involved in Breast Tumor Cell Growth.
Gérard Maillot, Magali Lacroix-Triki, Sandra Pierredon, Lise Gratadou, Sabine Schmidt, Vladimir Bénès, Henri Roché, Florence Dalenc, Didier Auboeuf, Stefania Millevoi, and Stéphan Vagner
Cancer Res 2009, Nov 1 ; 69 : (21) 8332-40

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